Pope Shenouda III
When we make the sign of the  cross, we remember many of its divine and spiritual meanings
  We remember God's love for us, who for  the sake of our salvation accepted to die for us: “All  we like  sheep  have gone astray; we have turned, every one, to his own  way; and the  Lord has laid on Him the iniquity of us all” (Is.53: 6). When we  make the sign of the cross, we remember “The Lamb of God who takes  away the sin of the world” (John.1: 29), and that “He Himself is  the propitiation for our sins, and not for ours only but also for the  whole world” (IJohn.2: 2)